Posted by JohnX on October 22, 2001, at 23:52:39
In reply to Re: medication poop-out questionaire, posted by Hattree on October 21, 2001, at 18:11:46
Its interesting that the Lamictal helps to tolerate
dexedrine. There is mounting evidence that glutamate
stimulated NMDA receptors (which lamictal would
modulate) are important to sensitization to these
types of meds. I have also found that Lamictal helps
with poop-out as well as Klonopin.I'm wondering about the marketability of new meds
in the pipeline like memantine (an NMDA receptor
antagonist) which has potentially unique properties to
prevent medication tolerance build up. There are
a number of companies chasing this route, but
memantine will likely be first out the door.
The people marketing the meds are actually going
for approval for Alzheimers,peripheral neuropathy,
and glaucoma, but physicians can prescribe it
for whatever as long is it is FDA approved.
Provigil for example, a narcolepsy med,
actually gets 80% of its scripts for
things other than narcolepsy.I see many uses in psychiatry for these new
class of meds (nmda antagonists). AndrewB posted
success with memantine to prevent Adderall tolerance.
Interestingly these meds, nmda-antagonists, are
also neuroprotective and would help keep the
other meds from frying neurons. It seems too good
to be true to have a med that is neuroprotective that
also prevents tolerance issues on other meds.Thanks for all the input.
I would also like to know if anyone has found
meds like Lamictal or others help with tolerance.-John
> The stimulants all poop out on me after a few days at a stretch (if poop out can be described as increased anxiety, depression and exhaustion). I took them at intervals to get myself out of particularly bad spots. However, along with Lamictal I seem to be able to tolerate dexedrine consistently.
>
> >
> > A few people on this newsgroup including myself
> > and SLS have posted issues with getting medication
> > responses that quickly "poop out".
> >
> > I was wondering if I could put a feeler out for
> > those who have had this issue. I would be interested
> > in knowing on what meds this happened and how it
> > occured, and in particular if this has been an issue
> > with quick acting meds like Adderall, Dexedrine,
> > Provigil, and Cylert.
> >
> > Thanks,
> > John
poster:JohnX
thread:81909
URL: http://www.dr-bob.org/babble/20011015/msgs/82034.html