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Re: Scott - medication responses?

Posted by JohnX on October 15, 2001, at 23:51:05

In reply to Re: Scott - medication responses?, posted by JohnX on October 14, 2001, at 20:48:39


Scott,

I wanted to clarify an error regarding
clonidine (besides my perpetual mispelling).
It is a partial agonist of the
presynaptic alpha-2 receptor and an antagonist
at the post-synpaptic alpha-2 receptor (not
the alpha-1). Whoops.

Regarding the 3-4 days magic number thingy,
it seems as though that is a typical amount
of time to up/down regulate beta-adrenoreceptors.
At least that's what my neurologist said when
he talked about Inderal. Don't know if there
is a correlation. But beta receptor down regulation is trademark sign of some older trycyclic antidepressants working.

My thinking at least in regards to my own experience, is that I also get this very abrupt lift from depression, usually accompanied by
either excersize or caffeine digestion. I usually
get an anti-depressant response about 4 days after
I hit the right dose. Adderall, the stimulant,
poops out on me after 4 days.

I read some interesting information about
poor "noradrenergic tone" and how clonodine could
help. The article was referring to childhood
trauma, but it could be easily extended to
cover a more broad based problem with noradrenergic tone.

http://www.childtrauma.org/ptsd_child.htm

This may not be pertinent to you scenario, but as you may know, depression associated with a
history of trauma or other certain illnesses is
generally more treatment resistant. But it seems
as though researchers are making better strides
in this area.

regards,
john



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