Posted by SalArmy4me on September 18, 2001, at 17:28:13
In reply to max wellbutrin dose, posted by gdog on September 18, 2001, at 15:25:05
I know quite a few people who take 450 mg. They often take 300 in the morning and 150 in the afternoon to minimize insomnia.
My view on Wellbutrin and seizures: I think that the risk of seizures associated with Wellbutrin is exaggerated. In the early studies, the rate of occurence was about 0.30 percent in general patient populations at dosages as high as 900mg. This is about equal to the tricyclics. More recent studies indicate that the SR (sustained release) version of Wellbutrin at dosages up to 300mg carries no greater risk to produce seizures than most other antidepressants; the rate being about 0.10 percent. However, the rate of seizure increases significantly in people with a pre-existing seizure disorder. It is also increased when treating people who have an imbalance of electrolytes such is seen in eating disorders like bulemia. The rate of seizure also increases at dosages greater than 300mg. Even so, the rate at 450mg is no greater than that of the tricyclics. I would not want to speculate at dosages exceeding 450mg. More frequent dosing helps to minimize risk. It was during a pre-marketing investigation designed to study the efficacy of Wellbutrin in treating bulimia that seizures emerged. I think most of the bad reputation this drug has was born of that study.
poster:SalArmy4me
thread:79007
URL: http://www.dr-bob.org/babble/20010917/msgs/79018.html