Posted by JohnL on September 13, 2001, at 18:00:07
In reply to Remeron vs Zyprexa, posted by SallyR on September 13, 2001, at 11:07:41
Hi Sally,
I was on Remeron for over a year, and now Zyprexa for about half a year. Of the two, I personally like Zyprexa a lot better. Remeron knocked me out fast at bedtime, which Zyprexa doesn't do (it takes a couple hours), but Remeron also gave me very poor quality sleep. Zyprexa gives me a real good quality sleep.My depression was characterized mainly by anhedonia, lack of pleasure, blahness. Remeron did absolutely nothing to fix that. I basically just survived for the year I was on it. For others though it works great, but I'm not sure they have the same kind of depression I was dealing with. Zyprexa for me felt good within 24 hours. I definitely knew I was on to something good right away.
Remeron and Zyprexa are actually somewhat similar in some ways, as far as working on various receptors and such, except that Zyprexa has action on dopamine receptors where Remeron does not. Remeron affects serotonin and norepinephrine, but Zyprexa affects serotonin and norepinephrine and dopamine. It has a wider spectrum, and maybe that's why it is proving useful in a wide range of disorders.
Some people will prefer Remeron. Some people will prefer Zyprexa. My personal choice is Zyprexa. My doc's choice is Zyprexa. Regardless of all the theory and talk of receptors and all that, my doc just plain has better luck with Zyprexa than Remeron. Me too.
John> I read alot on this board about both Remeron and Zyprexa as effective augmentors of SSRI's.
> Can anyone comment on the similarities and differences between these two drugs.
> Thanks in advance for your assistance.
poster:JohnL
thread:78718
URL: http://www.dr-bob.org/babble/20010907/msgs/78741.html