Posted by kregpark@yahoo.com on September 12, 2001, at 4:43:36
In reply to Re: MAO Midday Slump? Thank-you all nm » kregpark@yahoo.com, posted by Rick on September 9, 2001, at 15:58:33
Rick:
I first read of it in a couple journal articles since thrown away on treatment of MAOI side effects.
Prior to the "great SSRI's" MAOI use was more common and neostigmine and bethanechol (both cholinergics) were recommended for anticholinergic side effects (cognition, dry mouth, etc). Those effects actually are far more significant with many tricyclics, but are not that strong usually with MAOI's once adjusted to therapuetic dose.
I'd tried bethanechol which was a bit stimulating but I rarely took it, on a fluke a recent doc gave me neostigmine when I called in for bethanechol (it's been discontinued or else very hard to get - no big loss there probably)
Actually I'd only tried it once for energy on n + K and it does work!
Neostigmine activates the muscles sort of. Bethanechol's effect seems a bit different.\
Bethanechol tended to make me a bit aggressive (too much) - neostimine so far is prosexual, seems to substitute for
provigil partially reducing insomnia, and so far I've favored it, not going above 60mg provigil and 1/4 tab (very very little) in am neostigmine.
So far I like in AM because I take all Nardil then and am a bit more (I think) getting "anticholinergic" effect which may
make me less "upbeat" and less "horny" (is that an appropriate word here?)OK - on that note I better sign out.
kregpark
> I've never heard of neostigmine, although I looked it up. Was that prescribed for psychotrpoic purposes, or did you just accidentally discover that it helps mentally?
>
> I don't think I have manic episodes myself, although it's possible (they'd be classified as mild, though). I *do* usually find that when I feel mild euphoria or unusually "up" that life has been treating me well that day or that week, so I'm beginning to doubt that the unusually contented feeling is entitely due to meds and/or spontaneous brain chemistry. Most likely it's a pleasantly synergistic combination chemical and environmental. Spiking the Provigil up definitely adds to the likelihood of such a reaction for me, although as mentioned before, modafinil's been used safely in bp.
>
> Rick
>
> P.S. Do you prefer to be addressed as Kregpark?
> Please don't answer, "You can call me Kregpark, you can call me rick_1001, you can call me whatever you want. Just don't call me late for dinner."
poster:kregpark@yahoo.com
thread:76827
URL: http://www.dr-bob.org/babble/20010907/msgs/78631.html