Posted by Elizabeth on September 12, 2001, at 3:21:08
In reply to Re: Marplan » Elizabeth, posted by Grouch on September 9, 2001, at 21:38:28
> Marplan was the MAO that really got off on the wrong foot. Several early studies showed it to be a less than spectacular antidepressant, so doctors shied away from it. However, it was later recognized that these studies were significantly flawed.
I think the doses used were too small. Were there other flaws that you're aware of?
> There was also concern that Marplan might be toxic to the liver like its sister drug isoniazid (for TB), though time has shown this rarely to be a problem.
Isoniazid is a hydrazide drug, like Marplan and Nardil, but isoniazid is not a MAO inhibitor to any significant degree. It is still used in the treatment of TB, although liver function testing is recommended. Iproniazid (Marsilid), another anti-TB drug, was the first MAOI used for depression and did get taken off the market due to hepatotoxicity. Nardil can cause liver damage as well, although this too is rare.
> > Which came first: Trek ('66) or isocarboxazid? (I think Nardil and Parnate were first marketed in, respectively, '59 and '63.)
>
> There are Medline references to isocarboxazid as far back as '64 -- pre-Star-Trek era.OK, but which episode had the Marplan character?!!
(BTW, Medline citations may predate the assignment of a brand name to a drug.)
-elizabeth
poster:Elizabeth
thread:77178
URL: http://www.dr-bob.org/babble/20010907/msgs/78624.html