Posted by SalArmy4me on September 4, 2001, at 16:01:09
In reply to Wellbutrin - weight loss or appetite gain?, posted by Tony P on September 2, 2001, at 21:38:11
What about the possibility that you will lose weight due to a change in your metabolism on Wellbutrin, regardless of appetite?
Diabetes
Volume 50 SUPPLEMENT 2 June 2001 p A21
Buproprion SR Significantly Enhances Weight Loss When Used with a Moderate-Intensity Lifestyle Intervention:"Preliminary studies suggest that Bupropion SR, approved for depression and smoking cessation, is an effective adjunct to diet for weight loss. We conducted a 6-month multi-center, randomized, double-blind, placebo-controlled, parallel-group study to test the safety and efficacy of Bupropion SR as an adjunct to a balanced energy-restricted diet and lifestyle program to treat obese adults. We enrolled 327 women and men, aged 18-65 years, with BMIs of 30-43. We excluded subjects who had a history of seizures, anorexia, bulimia, depression, psychosis, cigarette or substance abuse. After a 2-week run-in period subjects were randomly allocated to placebo, 300 mg/day, or 400 mg/day Bupropion SR. The lifestyle intervention included an energy-restricted diet (600 kcal deficit), use of 2 meal replacements/day, recording miles walked (pedometer), and a lifestyle diary. Subjects received dietetic counseling every 2-4 weeks. Retention rate at 24-weeks was ~70% and was similar in all groups. The weight loss (% of initial weight) and loss of >5% at 6 months (intention to treat analysis) are summarized in table."
poster:SalArmy4me
thread:77387
URL: http://www.dr-bob.org/babble/20010902/msgs/77698.html