Posted by Rick on September 3, 2001, at 12:10:33
In reply to Re: (Dopamine and SP) » Rick, posted by Mitch on September 3, 2001, at 9:47:44
> What about a combination of
> 1) Klonopin
> 2) low dose SSRI
> 3) low dose pergolide (D2 agonist)?
Well, I'm just guessing here and the usual inter-person unpredictability applies. But 1+2 sounds good, although -- contrary to the typical doc-prescribed regimen, I'd start the K first.I once tried pergolide (Permax) as an augmentor to Klonpin (with no AD). A friend had tried it for periodic limb movements of sleep, and it it turns out simply increasing her [nighttime-only] Neurontin dose worked a lot better, and without the nasal congestion and other side effects of pergolide.)
So I tried adding some to my Klonopin. Maybe I popped too much pergolide on the first trial (I know you're supposed to ramp up slowly, but I wasn't all THAT much higher than recco'd amount. That was dumb, nonehelsess.) Anyway, it was a disaster, and I dumped it very quickly. (The movie I saw immediately after taking my first and only dose of Pergolide was punishment enough, without having to feel like I had sudden-onset flu at the same time!)
Given this experience, I wasn't at all to find a new study that showed Pergolide so ineffective in Social Phobics that the study was promptly killed. Here's the Medline listing in case you want to order the short article or search for more info. (There's no abstract).
Depress Anxiety 2000;11(1):45-47 Related Articles, Books, LinkOut
Treatment of social phobia with the dopamine agonist pergolide.Villarreal G, Johnson MR, Rubey R, Lydiard RB, Ballanger JC.
Publication Types:
Clinical trial
Letter
poster:Rick
thread:36517
URL: http://www.dr-bob.org/babble/20010902/msgs/77540.html