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Re: Roche calls it an anticonvulsant? » Squiggles

Posted by Cam W. on August 30, 2001, at 19:40:29

In reply to Re: Roche calls it an anticonvulsant?, posted by Squiggles on August 30, 2001, at 17:53:36

Squiggles - All benzodiazepines are anticonvulsants, to some extent, especially the fat soluble, long-acting ones like diazepam (Valium™) and clonazepam (Rivotril™/Klonopin™).

The neurotransmitter GABA (gamma-amino butyric acid) is an "inhibitory neurotransmitter". It inhibits the release of other neurotransmitters (serotonin, dopamine, norepinephrine), thus slowing electrical transmission in nerve cells. The slowing of nerve cell conduction is calming, and thus stops the spontaneous firing of nerve cells, seen in convulsions.

Benzodiazepines facillitates the binding of GABA to the GABA receptor complex (causes a conformational change in the GABA receptor complex, so that GABA binds to it more readily).

- Cam


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poster:Cam W. thread:76985
URL: http://www.dr-bob.org/babble/20010828/msgs/77009.html