Posted by SalArmy4me on August 28, 2001, at 0:21:01
In reply to Best meds for eating disorder(obesity) and depress, posted by Collete on August 23, 2001, at 19:38:40
"Preliminary studies suggest that Bupropion SR, approved for depression and smoking cessation, is an effective adjunct to diet for weight loss. We conducted a 6-month multi-center, randomized, double-blind, placebo-controlled, parallel-group study to test the safety and efficacy of Bupropion SR as an adjunct to a balanced energy-restricted diet and lifestyle program to treat obese adults. We enrolled 327 women and men, aged 18-65 years, with BMIs of 30-43. We excluded subjects who had a history of seizures, anorexia, bulimia, depression, psychosis, cigarette or substance abuse. After a 2-week run-in period subjects were randomly allocated to placebo, 300 mg/day, or 400 mg/day Bupropion SR. The lifestyle intervention included an energy-restricted diet (600 kcal deficit), use of 2 meal replacements/day, recording miles walked (pedometer), and a lifestyle diary. Subjects received dietetic counseling every 2-4 weeks. Retention rate at 24-weeks was ~70% and was similar in all groups. The weight loss (% of initial weight) and loss of >5% at 6 months (intention to treat analysis) are summarized in table.
Bupropion SR at 300 and 400 mg/day were associated with significantly more weight loss than placebo. This analysis suggests that the weight loss response to Bupropion SR is dose related. This study indicates that, in conjunction with a reduced-energy diet and exercise program, Bupropion SR can significantly enhance weight loss in a dose-related manner for obese subjects."
poster:SalArmy4me
thread:76164
URL: http://www.dr-bob.org/babble/20010822/msgs/76675.html