Posted by rick_number1001@yahoo.com on August 24, 2001, at 8:52:19
In reply to Bupropion SR - Wow! Great Social Phobia response!, posted by jb on March 28, 2001, at 19:00:39
Hi JB:
Several years ago Wellbutrin did me no good taken
with Zoloft + Klonopin (was a negative)However, I have added it low dose this past year
with Nardil 60mg and Klonopin 2.5mg (50-100 bupropion)
and it was a helpful augment! It boosted libido and
sociability. Actually as I recall I did better by
going to about 68 Nardil at the same time.I only stopped because I preferred augmenting
50-100 Provigil to the Nardil + Klonopin.
The Wellbutrin sometimes made me a bit aggressive
at work on occasion, but in many work environments
I think the same behavior would not have been
"overagressive"So yes I like like it! I also liked it with Xanax.
I'd like to see Xanax SR be released because
I think it would work great with bupropion or
Parnate, for example, for the treatment of Social Phobia!!
:)Craig (Rick_number1001@yahoo.com)
www.socialfear.com
> To date, I've seen little, outside of limited clinical experience, to suggest Wellbutrin (Bupropion) might be effective in treating generalized social phobia. There's a paucity of research, but I discovered the article, below, in a search of PubMed. Keep in mind that the sample size is very small, so it's difficult to say anything other than it's maybe worth a try. What I find interesting, however, is the authors'high hurdle rate for what they considered responders. That is, the patients had to have either a CGI score of 1 or 2, meaning "much improved" or "very much improved," in addition to a greater than 50% reduction in baseline social phobia. Of the 10 subjects who completed the regimen, 5 were considered "responders."
>
> I believe this is a very different definition of "responders" from those use in some other studies, whereby the term is used for anyone showing "moderate" to "marked" improvement. I understand the CGI to be a somewhat subject score, as opposed to change in BSPS. I don't know about others of you, but I have found the loose definition of "responders" to be confusing, to say the least. Just take another look at PubMed research, and I think you'll see what I mean. Also, I haven't seen any research in which the definition of "responders" also much include a greater than 50% reduction in BSPS.
>
> Back to the subject at hand, this limited sample size results for Bupropion, given the very strict definiton of "responders" is very exciting, particularly given Bupropion's relative lack of side effects.
>
> Has anyone with Social Phobia had a similar experience, at the equivalent dosage cited in the research (mean of 368 mg/day)?
>
> JB
>
>
> Depress Anxiety 2000;12(2):111-3 Related Articles, Books
>
>
> Bupropion-SR in treatment of social phobia
>
> Emmanuel NP, Brawman-Mintzer O, Morton WA, Book SW, Johnson MR, Lorberbaum JP, Ballenger JC, Lydiard RB
>
> Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425, USA. emmanunp@musc.edu
>
> [Record supplied by publisher]
>
> A 12-week, open label flexible dosing study was conducted to evaluate the efficacy of bupropion-SR in the treatment of generalized social phobia. The primary outcome measures include the Clinical Global Impression of Improvement (CGI-I) and the Brief Social Phobia Rating Scale (BSPS). A total of 18 subjects were enrolled. Five of the ten subjects who completed all 12 weeks were considered as responders. Response to treatment was defined as a CGI-I score of 1 or 2, ("much improved" or "very much improved," respectively) and a > 50% decrease in BSPS score. The final doses for the completers ranged between 200 and 400 mg/day (mean 366 +/- 68 mg/day). The medication was generally well tolerated. Findings from this open-label trial suggest that bupropion-SR may be useful in treating generalized social phobia
poster:rick_number1001@yahoo.com
thread:57847
URL: http://www.dr-bob.org/babble/20010822/msgs/76212.html