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Re: Taking stimulants - Memantine, Selegiline?

Posted by SLS on August 23, 2001, at 19:36:51

In reply to Re: Taking stimulants - Memantine, Selegiline?, posted by Cindylou on August 23, 2001, at 13:08:24

> Hello,
> Andrew B. discussed the possibility of adding Memantine to Adderall to help keep Adderall from "pooping out" --

Yes. His discovery is very exciting. He's a real smart guy.

I am becoming interested in using memantine to augment antidepressants rather than stimulants. I am hoping that my partial response to Lamictal (lamotrigine) is a prognosticator of efficacy.


> Has anyone out there taken Memantine before? Is it FDA approved yet? I did a small bit of research on the web, and it seems to still be in clinical trials.

It is being studied as a treatment for Alzheimer's Dementia.

> Also, does anyone know if it is safe to take with Prozac??

I wouldn't think there would be a problem, but Andrew would be a better judge of that.


> Another question -- is Selegiline safe to take with Prozac? Has anyone out there taken this combo? I read conflicting reports in the archives on this issue -- wondering if there are any new experiences, opinions, etc.

Generally, it is thought that low dosages of selegiline - 10mg or less - does not affect serotonin in such a way as to cause a problem with Prozac (serotonin syndrome). However, I see that there are some reported incidents on Medline. Personally, I would not be comfortable with trying this combination without receiving input from doctors and patients who have experience with such a combination.

Two conflicting opinions:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9109902&dopt=Abstract

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9167831&dopt=Abstract


- Scott

 

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