Posted by Sunnely on August 18, 2001, at 23:32:07
In reply to Be Careful With L-Phenylalanine , posted by BrainSurge on August 18, 2001, at 9:09:21
The following conditions or diseases may worsen with the use of phenylalanine:
1. Alkaptonuria: Contraindicated. Alkaptonuria is an inherited disorder involving the inability to metabolize phenylalanine and tyrosine, leading to ochre pigment deposits in the connective tissues. There are no clinical manifestations until mid-adulthood, when the pigment deposits lead to progressive degenerative joint diseases.
2. Hypertension: Use with caution in patients at risk for hypertension. Some evidence suggests that L-phenylalanine might cause hypertension in genetically predisposed patients.
3. Phenylketonuria (PKU): Contraindicated. Phenylketonuria is an inherited disorder involving the inability to metabolize phenylalanine, leading to toxic serum levels of phenylalanine and its metabolites.
4. Schizophrenia: Use with caution. L-phenylalanine can exacerbate tardive dyskinesia (TD) in people with schizophrenia.
5. Stroke. Use with caution in patients at risk for stroke. Some evidence suggests that L-phenylalanine might increase the risk of stroke in genetically predisposed patients.
6. Tyrosinemia/Tyrosinuria: Contraindicated. Tyrosinemia is an inherited disorder involving the inability to metabolize tyrosine leading to toxic serum levels of tyrosine and its metabolites. Because phenylalanine is metabolized to tyrosine, it can also cause toxic tyrosine levels in people with tyrosinemia.
poster:Sunnely
thread:75486
URL: http://www.dr-bob.org/babble/20010814/msgs/75555.html