Posted by Elizabeth on August 8, 2001, at 6:12:59
In reply to PROVIGIL AND NARDIL COMBO, posted by TICE2001 on August 8, 2001, at 4:45:37
Actually, from what I've heard, Provigil is probably used more off-label than for its labelled use (narcolepsy). Note that it isn't labelled as a treatment for narcolepsy, but rather, for "excessive daytime sleepiness associated with narcolepsy." It's been found useful in both childhood and adult ADD, as well as EDS in conditions besides narcolepsy.
I tried adding Provigil to Parnate (60 mg). 150 mg of Provigil didn't do anything noticeable, but 200 mg made me very jittery. My blood pressure was also modestly elevated (around 130/85, I think). The 200 mg dose did, however, improve my concentration and focus.
It's mechanism of action is unknown but may involve glutamate (increasing rekease), GABA (decreasing release), dopamine (blocking reuptake), and/or norepinephrine (activating alpha1-adrenergic receptors, directly or indirectly) at specific sites. Some of the results have been seemingly contradictory.
-elizabeth
poster:Elizabeth
thread:74098
URL: http://www.dr-bob.org/babble/20010804/msgs/74102.html