Posted by SalArmy4me on July 29, 2001, at 15:03:25
In reply to Re: Experience with trileptal?, posted by Emme on July 29, 2001, at 11:17:52
It once was overwhelmingly helpful until it pooped-out (Tegretol XR).
"Institution
Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA.Title
Valproate and carbamazepine increase prefrontal dopamine release by 5-HT1A receptor activation.Source
European Journal of Pharmacology. 380(1):R1-3, 1999 Sep 3.Abstract
The anticonvulsant mood stabilizers valproic acid (250, 500 but not 50 mg/kg) and carbamazepine (6, 12.5 but not 3 mg/kg) were found to increase extracellular dopamine levels in rat medial prefrontal cortex, but not nucleus accumbens. Increased prefrontal dopamine was completely abolished by the selective 5-HT1A receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexa necarboxamide (WAY100635, 0.05 mg/kg). Anticonvulsants and clozapine may share a common mood stabilizing mechanism since clozapine is reported to have mood stabilizing effects and increase prefrontal dopamine by 5-HT1A receptor activation."
poster:SalArmy4me
thread:71844
URL: http://www.dr-bob.org/babble/20010725/msgs/72388.html