Posted by SalArmy4me on July 26, 2001, at 23:47:23
In reply to Topamax: Something New, posted by Elzabeth on July 26, 2001, at 23:40:00
KUPKA, RALPH W. The Stanley Foundation Bipolar Depression Network: 2. Preliminary summary of demographics, course of illness and response to novel treatments+. British Journal of Psychiatry. 178 SUPPLEMENT 41:s177-s183, June 2001:
"Of the 54 patients treated with topiramate, 30 were in a manic, hypomanic, mixed or extremely rapid cycling state, 11 were depressed and 13 were relatively euthymic. The euthymic patients received topiramate for psychotropic drug-induced weight gain and/or binge eating, since this drug has shown anorectic and weight-loss effects in clinical trials in patients with epilepsy. Significant improvement of manic symptomatology was seen in the first subgroup (patients who were initially in a manic, hypomanic, mixed or rapid cycling state), with 63% rated as responders after 10 weeks, while only 27% of the depressed group showed much improvement in their depressive symptoms. The group of euthymic patients showed no significant changes in mood ratings. On the average there was a significant reduction of weight (down 4.9%) and body mass index (down 5.0%) in the whole group of patients..."
poster:SalArmy4me
thread:71988
URL: http://www.dr-bob.org/babble/20010725/msgs/71992.html