Posted by AndrewB on July 19, 2001, at 10:02:19
In reply to Memantine and Aniracetam » AndrewB, posted by Jean Paul on July 18, 2001, at 11:25:14
Jean Paul,
Is the Aniracetam and Memantine combo. safe? I can give you some general thoughts. Aniracetam is a one of a class of neurotropics of which piracetam is the oldest and best known. They are called neurotropics because of their ability to improve cognitive function to a very moderate degree in most healthy people and sometimes to a robust degree with a memory impaired person. Aniracetam and its analogues work by increasing glutaminergic activity in the hippocampus (they are very specific in their mode of action). Of this class of neurotropics, aniracetam is the most effective at increasing hippocampal glutaminergic activity. Hippocampal function, and specifically its glutaminergic activity, is one of the essential elements to memory function. Interestingly, a more powerful activator of hippocampal glutaminergic activity is in testing stages as a memory enhancer. It is called Ampalex. It increases glutaminergic activity by modulating one (of the three) glutamate receptors, the AMPA receptor. Remember, Memantine puts a physiological upper limit on glutaminergic activity via the NMDA glutaminergic receptor.
Aniracetam hasn't been associated with any neurodegenerative effects in studies. But then again, no longterm studies have been done to see if it could cause excessive glutaminergic hippocampal activity which could, over a period of years, damage the hippocampus. Memantine, I think would act as a 'safener'. That is a drug that insured that glutaminergic activity did not increase beyond the safe physiogical limits in the hippocampus. That being said, I seem to need 30mg.s of Memantine a day (20mg in the morning, 10mg. in the evening) for it to control Adderall's activity effectively. You could try a slightly higher dose and see if you have a more stable effect.
I have tried Aniracetam myself but without effect. I have never tried it with Memantine though. What kind of effect are you experiencing with Aniracetam. Is it strictly improved memory. Has cognition improved. Too what degree? Are there any non-cognitive efffects. I find this very interesting. Also, is there anything else new that you are experiencing with your med. combo. in general?
Best wishes and looking forward to your response,
AndrewB
poster:AndrewB
thread:69983
URL: http://www.dr-bob.org/babble/20010714/msgs/70835.html