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Remeron: Only 15 mg Is Really Needed

Posted by SalArmy4me on July 16, 2001, at 2:50:13

From Dr. Preskorn, Professor and Chair of the Department of Psychiatry and Behavioral Sciences at the University of Kansas School of Medicine - Wichita.
http://www.preskorn.com/cgi-bin/sp.pl?words=clomipramine&wt=be&bl=an&d=/books/omd_s7.html

"There are no published fixed-dose studies which empirically establish that doses of mirtazapine higher than 15 mg/day are more effective or better tolerated. There are anecdotal and theoretical reasons to suspect that higher doses will decrease the problem of sedation (ie, offsetting arousal effects as a result of alpha-2-adrenergic blockade at higher concentrations [Figure 6.4])..."

Source: Janicak PG, Davis JM, Preskorn SH, Ayd FJ Jr. Principles and Practice of Psychopharmacotherapy. 2nd ed. Baltimore, Md: Lippincott, Williams & Wilkins; 1997.


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