Posted by Simcha on July 13, 2001, at 14:54:25
In reply to PELLMELL: re Effexor and NE, SRI, etc:, posted by Janelle on July 13, 2001, at 13:46:33
Janelle,
I was on 150mg EffexorXR and I had the sweats characterized by hightened amounts of Norepinephrine. My heart would beat faster during my workout. My doc said that 150mg was enough to cause these side effects. My side effects lessened the longer I took EffXR.
> Thanks for that info ... believe it or not I knew that Paxil (which I was on for many years) inhibits norepinephrine reuptake a bit, more than any other SSRI and that Effexor is a norepinephrine *and* serotonin reuptake inhibitor.
>
> However, I did not know one would have to go ABOVE 150 mg [the lowest theraputic dose for depression], for it to affect NE significantly as well, nor that this action on NE might not have any clinical significance, though.
>
> But what do you mean by in light of this, maybe the NE action of Effexor isn't what's causing me trouble? At the low dose I'm on and even at 150 mg that awful day, from what you mentioned, I would not be having NE action from Effexor. So, maybe you're saying that Effexor not seeming to work for me has nothing to do with its NE action since I'm not getting its NE action at the dose I'm on? Hmmmmm ...
>
> What do the **'s mean?
>
> (and how do you know SOOOOOOO much - do you work in the med field, do a lot of reading, both? just curious, thanks!)
poster:Simcha
thread:70013
URL: http://www.dr-bob.org/babble/20010708/msgs/70017.html