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Estradiol Treatment of Post-Menopausal Depression

Posted by SalArmy4me on July 10, 2001, at 1:50:04

Archives of General Psychiatry June 2001 (Not from Medline) Efficacy of Estradiol for the Treatment of Depressive Disorders in Perimenopausal Women: A Double-blind, Randomized, Placebo-Controlled Trial.
de Novaes Soares, Claudio MD, PhD. Almeida, Osvaldo P. MD, PhD. Joffe, Hadine MD. Cohen, Lee S. MD.:

"The results of this study indicate that estradiol is an effective antidepressant treatment for women in perimenopause. Previous reports had already shown that estrogen replacement therapy improves menopausal somatic symptoms, subjective well-being, and quality of life during perimenopause. 11-12, 25 Recently, in a 6-week study, Schmidt and colleagues 18 found that the use of 50 µg of 17[beta]-estradiol improves mood in perimenopausal women who meet standardized criteria for major and minor depression. Our results support these findings, as estradiol improved mood in subjects with depressive disorders. Estradiol therapy was efficacious in treating depressive symptoms in a larger sample of women who met criteria for MDD (n = 26)—67% of those receiving estradiol had full remission of depression. In addition, we were able to demonstrate the occurrence of continued mood improvement throughout the 12-week treatment phase (decreasing MADRS scores consecutively observed at weeks 4, 8, and 12). Our findings obtained with 100 µg of estradiol contrast with the aforementioned study, 18 which used a lower dose of estradiol, and in which increasing improvement in mood occurred only during the first 3 weeks of treatment."


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