Posted by AMenz on July 9, 2001, at 10:52:07
In reply to Re: Going Crazy: Could it be Buspar????? » Elizabeth, posted by Mitch on July 8, 2001, at 16:45:45
Let's take this a step at a time. Please help me here.
"Buspirone (0.01-2.5 mg/kg, s.c.) dose-dependently decreased dialysate levels of serotonin (-50%), and increased those of dopamine (+100%) and noradrenaline (+140%)."Also what is WAY 100,635 and why are they mentioning it here if they are doing a comparison of fluoxetine and buspirone alone and in combination?
"The reduction by buspirone of serotonin levels was abolished by the serotonin1A receptor antagonist, WAY 100,635 (0.16), which did not, however, modify its influence upon dopamine and noradrenaline."
Next fluoxetine increases extracellelar levels of serotonin:
"In contrast to buspirone, the serotonin reuptake inhibitor, fluoxetine (10.0), increased frontocortical levels of serotonin (+ 120%), dopamine (+55%) and noradrenaline (+90%)."
Together Buspirone reduces the serotonin levels as enhanced alone by fluoxetine:
"Buspirone dose-dependently (0.01-2.5) decreased the induction by fluoxetine of serotonin levels yet potentiated (three-fold) its elevation of dopamine and noradrenaline levels."
But then you come to the agonist properties of buspirone at the serotonin1A receptor. What does this entail? Does it increase certain intracellular activity because it mimics seratonin so that the cell acts as if seratonin were enhanced instead of diminished?
"In conclusion, the inhibitory influence of buspirone upon resting and fluoxetine-stimulated serotonin levels reflects its agonist properties at serotonin1A autoreceptors. The facilitatory influence of buspirone upon resting and fluoxetine-stimulated dopamine and noradrenaline levels may also involve its serotonin1A properties."
OK so my questions in closing are:1)what is the consequence of this mimicking effect.
2) more seratonin equals more mania and less seratonin depression
3) do they have any idea as to effect of dopamine and noradrenaline on mood?
Thanks for any help with these questions. ARe doctors reluctant to discuss these issues because they think their patients are too stupid or because they themselves don't read?
poster:AMenz
thread:69089
URL: http://www.dr-bob.org/babble/20010708/msgs/69462.html