Posted by SalArmy4me on July 1, 2001, at 19:15:48
In reply to anyone on desyrel?, posted by Moore on July 1, 2001, at 7:29:07
Hertzberg, Michael A. MD et al. "Trial of Trazodone for Posttraumatic Stress Disorder Using a Multiple Baseline Group Design." Journal of Clin. Psychopharmacology. 16(4):294-298, Aug 96:
"...Thereafter, as long as side effects remained insignificant, the dosage was increased 100 mg monthly to 400 mg at 3 months. This very gradual dosing schedule was chosen in order to reduce the development of intolerable side effects. If side effects were significant (e.g., hypersomnolence), dosing was altered. If the therapeutic dose was achieved before 400 mg as determined by the treating physician, no further increases were made. The mean therapeutic dose was 300 mg (range 150-400 mg). All medication was taken at one dose before bedtime. Medication side effects were rated by means of a 34-item checklist, which was presented to the patient at baseline and then repeated at each visit. Only one of the six subjects reported a significant side effect (rash in 3rd treatment month), but was then titrated at a slower pace across the treatment period with no further occurrence of rash..."
poster:SalArmy4me
thread:68593
URL: http://www.dr-bob.org/babble/20010701/msgs/68644.html