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Re: moclobemide » may_b

Posted by Elizabeth on June 27, 2001, at 23:44:04

In reply to Re: moclobemide, posted by may_b on June 27, 2001, at 10:02:58

> Hi Elizabeth
>
> Thanks for your helpful response.

You don't know how gratifying it is to be told that I've been "helpful." Thanks :-)

> The anergia, loss of focus was present before, but much worse after starting Moclobemide.

Gosh. I'd give it a chance, but if this hasn't at least started to clear up in a couple weeks, it probably won't be worth it (IMO).

> This explains a lot. I had one morning where i thought there was movement but it was followed by many very bad days -- worse than before I started it. Spiralling down. Emotional fragility -- overreactive to the least frustration, poor cognitive functioning. I am wondering how much time to give it, since I have much work to do for which I need my noggin.

The "emotional fragility" you describe is *exactly* the kind of thing that classic MAOIs help with. Tricyclics have been known to make it worse. SSRIs can too, in the short term, although they often help if you are able to tolerate them long enough.

You know, there is an irreversible, type-A-selective MAOI -- clorgyline -- but I don't think it was ever used clinically. I wonder how it would compare to Nardil and Parnate, in terms of side effects, efficacy, and interactions with foods and drugs.

> I am in Canada. No problem to obtain it here. Would you still think it worth pursuing?

Depending on your situation -- can you afford to be feeling crappy for a couple more weeks? It might subside, and if it did and the Manerix turned out to work, that would be a blessing.

> > Some people need benzodiazepines when they first start an antidepressant-
>
> This is a helpful clue. Yesterday was my first day of disabling anxiety.

I really recommend that you try to get some Rivotril or the like, then.

> Thanks so much for your excellent feedback.

You're very welcome. I'm glad I can help.

best wishes & hopes,
-elizabeth


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