Posted by SalArmy4me on June 16, 2001, at 11:12:57
Journal of Clinical Psychopharmacology
Volume 20(6) December 2000 pp 716-717:Orlistat in the Treatment of Psychopharmacologically Induced Weight Gain
These are the first reports of orlistat administration in obese patients receiving psychopharmacologic medication. This medication was very well tolerated by both patients ...1st Patient: her body weight increased significantly during paroxetine and lithium treatment; in the second case, the patient also showed a substantial weight gain and even new obesity occurred with paroxetine. In both patients there seemed to be a relationship to the psychotropic medication that could not be easily changed because of the course and severity of the underlying psychiatric disorder. Orlistat had the advantage not to be centrally active, so it did not interfere with the psychiatric disorder as one might have expected in the case of the new serotonin-noradrenaline reuptake inhibitor and appetite-suppressive drug sibutramine. Nevertheless, orlistat led only to an additional decrease in weight, but it was comparable to that achieved in former studies in patients without psychiatric disorders. In summary, orlistat might be a tool to help control weight in selected patients with psychotropic drug-associated obesity."
Ion Anghelescu, MD
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thread:66720
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