Posted by SalArmy4me on June 15, 2001, at 23:44:37
In reply to Lamital and pregnancy, posted by Ted Pierik on June 15, 2001, at 14:29:38
Ohman, Inger. Vitols, Sigurd. Tomson, Torbjorn *. Lamotrigine in Pregnancy: Pharmacokinetics During Delivery, in the Neonate, and During Lactation. Epilepsia. 41(6):709-713, June 2000:
Conclusions: "Our data demonstrate a marked change in maternal LTG kinetics after delivery, possibly reflecting a normalization of an induced metabolism of LTG during pregnancy. LTG is excreted in considerable amounts in breast milk (the dose to the infant can be estimated to >=0.2-1 mg/kg/day 2-3 weeks postpartum), which in combination with a slow elimination in the infants, may result in LTG plasma concentrations comparable to what is reported during active LTG therapy. No adverse effects were observed in the infants, however."Tomson, Torbjorn. Lamotrigine in Pregnancy and Lactation: A Case Report. Epilepsia. 38(9):1039-1041, Sept 97:
"Plasma levels of LTG decreased as pregancy progressed. The ratio of dose to plasma concentration was 5.8 times higher at delivery and 3.6 times higher in late pregnancy as compared with 5 months postpartum, suggesting enhanced clearance of LTG during pregnancy. The concentration ratio of umbilical cord to mother's plasma was 1.2 indicating extensive passage of LTG over the placenta. The LTG plasma concentration in the newborn was still 48 h after birth similar to the plasma levels of the mother at delivery and in the umbilical cord. The ratio of milk to plasma concentration was 0.6 2 weeks after delivery and the plasma concentration in the breast-fed child was 25% of the mother's plasma levels. No adverse effects were observed in the newborn."
poster:SalArmy4me
thread:66574
URL: http://www.dr-bob.org/babble/20010612/msgs/66645.html