Posted by Jean Paul on June 10, 2001, at 20:00:18
In reply to Re: Selegiline + Pemoline: is it safe? » Jean Paul, posted by SalArmy4me on June 10, 2001, at 18:46:35
Thanks for your post. I am speculating the following: the interaction may be severe if is true that pemoline acts as the amphetamines on the release of catecholamines, but as far as I know it affects dopamine more exclusively than amphetamines (which adrenergic effects are more active). Pemoline has very low sympathicomimetic action (at least that´s my experience with moderate dosages). But I won´t check this hypothesis with self-experimentation, so I may review other alternatives for boosting dopamine. Any idea? What about bromocriptine: is it a MAO B inhibator too?
> From the Drug Checker at www.drkoop.com:
>
> 1. Severe Interaction between pemoline and selegiline
>
> Amphetamines may precipitate severe hypertensive reactions in patients taking MAOIs. MAOIs cause an increase in norepinephrine storage in adrenergic neurons. Amphetamines liberate catecholamines resulting in an exaggerated effect in patients taking MAOIs. Death has been reported. Patients should be counseled to avoid concurrent use of MAOIs and amphetamines (and related drugs).
>
> References:
> 1. Cuthbert MF, Greenberg MP, Morley SW. Cough and cold remedies: a potential danger to patients on monoamine oxidase inhibitors. Br Med J. 1969;1:404-6. more info
> 2. Dally PJ. Fatal reaction associated with tranylcypromine and methylamphetamine. Lancet. 1962;1:1235-6.
> 3. Elis J, Laurence DR, Mattie H, Prichard BN. Modification by monoamine oxidase inhibitors of the effect of some sympathomimetics on blood pressure. Br Med J. 1967;2:75-8. more info
poster:Jean Paul
thread:66051
URL: http://www.dr-bob.org/babble/20010605/msgs/66065.html