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Re: prozac/serzone combo » gp

Posted by Sunnely on June 4, 2001, at 23:58:14

In reply to prozac/serzone combo, posted by gp on June 3, 2001, at 16:45:54

Hi gp,

Believe it or not, the combination of Prozac + Serzone may provoke or worsen anxiety.

Serzone is metabolized into 3 main compounds. One of these metabolites is called meta-chlorophenylpiperazine or mCPP, which is supposedly an "anxiogenic" (induces anxiety) compound. This metabolite appears to be broken down by an enzyme called CYP2D6. Prozac is known to markedly inhibit the action of this enzyme, which could to decreased clearance of mCPP, in turn leading to increased anxiety.

*****************************

> Has anyone used this mix to temper the anxiety from Prozac?


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