Posted by SLS on June 3, 2001, at 14:01:07
In reply to Re: Manerix/Moclobemide results? , posted by dave_fox on June 3, 2001, at 12:55:13
> Anna, I would really appeciate it if you could post some links to where I can read about Moclobemide poop-out. Thank you very much.
>
> BF
Hi BF.Are you currently taking moclobemide? At what dosage? How long have you been taking it? What are you being treated for?
I am also interested in what strategies are commonly used to compensate for moclobemide poop-out. Moclobemide is notorious for requiring higher and higher dosages to maintain its therapeutic effect. Some people take 1200mg and higher. I don't often read of it being used successfully for the more severe depressions. However, I sometimes encounter stories of people with more moderate depressions or social anxiety who do well on it. It produces a therapeutic effect very quickly - often in the first week. For most people, moclobemide is almost without side effects. In Finland, it was the most often prescribed antidepressant, and may still be. In New Zealand, it fell from being prescribed often as a first choice to not being prescribed at all for lack of efficacy.
If you are unable to recapture an antidepressant response to moclobemide by either raising the dosage or augmenting it with other drugs, you might consider trying Nardil. Nardil is a non-selective irreversable MAOI, so adhering to the special diet will be necessary. I have been on and off the diet for years. It is not such a big deal. My gut feeling is that Nardil is more similar to moclobemide than is Parnate. Perhaps Parnate does not inhibit MAO-A to the same degree as does Nardil or moclobemide.
Moclobemide can work miracles for some people. I hope you are one of them.
Good luck.
- Scott
poster:SLS
thread:13507
URL: http://www.dr-bob.org/babble/20010530/msgs/65258.html