Posted by Cam W. on May 18, 2001, at 23:20:07
In reply to Moban (molindone) for depression? EPS?, posted by SLS on May 18, 2001, at 21:07:23
Scott - I don't have much experience with Moban™ (molindone), as it is not available in Canada, but I have heard it mentioned by our head psychiatrist and by some visiting lecturers that molindone doesn't seem to be an effective antipsychotic. I believe it was Dr.Herbert Meltzer who said that the reason no one gained weight with molindone because they were too psychotic to eat (not positive on the quote; two days of lectures and they begin to blend together). I have heard that it is a safe drug, but I do not know it's propensity for causing EPS, if at all.
As for trying molindone as an andepressant augmenter in bipolar depression, I think that this might be worth a try. I would be interested to see molindone's secondary-receptor binding profile. Since it binds with high affinity to the 5-HT1A receptor, it should have a potent anxiolytic effect, possibly a lot like BuSpar™ (buspirone). Molindone is an FDA-approved drug looking for a new indication, much like Desyrel™ (trazodone) did when it switch from an antidepressant to a hypnotic.
Go for it, dude and keep us updated on your progress. - Cam
poster:Cam W.
thread:63543
URL: http://www.dr-bob.org/babble/20010515/msgs/63576.html