Posted by SLS on May 18, 2001, at 20:59:10
In reply to Re: Zyprexa just quit working/dose info? Angie, posted by katrina on May 18, 2001, at 17:52:08
Hi Katrina.
> My doc suggested a AP called Moban cuz for BPII the AD effects of zyprexa will poop-out
Thanks for posting.
My doctor mentioned Moban (molindone) also. It would be used as an augmenter of antidepressants for my bipolar depression.
What symptoms are you trying to use Moban to treat?
I am having trouble putting together a concrete profile of this drug. It is sometimes referred to as an atypical antipsychotic (Zyprexa, Risperdal, Clozapine, Seroquel, Geodon) and sometimes is grouped with the typical antipsychotics (Thorazine, Haldol, Prolixin, Stelazine, Navane). Antipsychotics are defined as atypical when they produce less EPS movement side effects and possess a reduced risk of producing tardive-dyskinesia compared to the older typical antipsychotics. My doctor tends to qualify Moban as being more atypical. From performing a Medline literature search, I am inclined to place Moban in a position near to Risperdal with Moban having a slightly more typical profile; both drugs being less atypical than Zyprexa and Clozaril.
Other properties sometimes ascribed to Moban include a moderate preference for presynaptic autoreceptors and a weak inhibition of MAO-A. This is a pretty poorly investigated drug for the number of years it has been in existence. It has been around since the 1960s, and was approved for marketing in 1974.
Moban is probably the only antipsychotic that produces weight loss.
I don't know how to feel about Moban. Like anyone else, I am not thrilled to be on a drug that has the capacity to produce EPS and tardive-dyskinesia. I don't know what the true incidence of EPS is for Moban, but my impression is that it is higher than the atypicals as a class. However, I believe there is sufficient reason to consider its use to treat refractory depression.
Sometimes, doctors know better than Medline. If there comes a time when my doctor urges strongly for me to try Moban, I will be inclined to try it.
- Scott
poster:SLS
thread:63349
URL: http://www.dr-bob.org/babble/20010515/msgs/63540.html