Posted by Dr. Bob on April 17, 2001, at 10:38:00
In reply to Richelson-GABA antagonists, posted by PaulB on April 12, 2001, at 17:56:16
> Because the benzodiazepines are unselective for GABA receptors and stimulate gabergic receptors involved in reducing anxiety and panic as well as those receptors involved in sedation I was wondering whether benzodiazepines could be augmented with selective GABA antagonists to allow a person to continue to experience the anxiolytic effect of the drug but eliminate the amnesic and sedative effects that the benzodiazepines have? Can you mention any that are available?
Great question, but no answer at this time. I am not aware of any selective antagonists for the benzodiazepine binding site that are clinically available or are in clinical development.
poster:Dr. Bob
thread:59594
URL: http://www.dr-bob.org/babble/20010417/msgs/60179.html