Posted by sherry gomez on March 24, 2001, at 10:34:15
In reply to Re: Update » shelby, posted by SLS on March 23, 2001, at 8:28:30
> Hi Shelby,
>
> Regarding nortriptyline:
>
> > So at least I know that I can still play around with dosages and will do so after antibiotics for my tooth
>
> Nortriptyline (Pamelor) is perhaps the only tricyclic antidepressant that demonstrates a true therapeutic window. You can actually take too much and lose the antidepressant effect. You can play with dosages, but you have a limited range with an upper and lower limit within which you must stay.
>
> The window for nortriptyline is rather narrow. The only way to be sure where you are within the window is to take blood tests to determine blood-levels. Nortriptyline has been the most heavily studied tricyclic drug with respect to therapeutic blood levels.
>
> The range for therapeutic blood concentrations of nortriptyline lies between 50 and 150 ng/ml (nanograms per milliliter).
>
> I have recently switched from desipramine to nortriptyline. After ten days (5 half-lives) at 100mg, my blood level was 123ng/ml. I will have a better idea next week as to how much flexibility there is in the therapeutic window for any one individual.
>
>
> - Scott
.
> >Scott,Is depakote Er good for depression? I take 1500mg along with topamax.....
poster:sherry gomez
thread:56899
URL: http://www.dr-bob.org/babble/20010319/msgs/57373.html