Posted by JohnX on March 13, 2001, at 23:41:33
In reply to Re: What is restless leg syndrome?-no post, posted by Mr. Scott on March 13, 2001, at 20:00:54
> Very interesting.. I always seem to develop pain from constantly flexing my muscles while on any SSRI or Wellbutrin.. Does this sound related to RLS to you? I also have fibromyalgia or so they tell me which might explain why the restlessness leads to pain??!!
Generally RLS is associated with some sort of hypo-dopaminergic functioning. The medications that can address it are dopamine meds like Mirapex & carbidopa/levodopa , beta-blockers like Inderal (unknown mode of action, probably related to a side effect of the med which acts on serotonin modulating 5ht-1 receptors to inhibit serotonin impulses that inversely modulate dopamine firing), meds with 5ht-2 antagonism like Serzone (where the 5ht-2 antagonism indirectly increases dopamine), and benzodiazepines like Klonopin.
A lot of people taking SRI meds complain about RLS, but I haven't heard of Wellbutrin generally being a suspect (it hardly touches serotonin). Maybe the insomnia it can cause makes you feel restless? RLS can definately be a fybromyalgia symptom as you referred too, although the roots of fybromyalgia seem to be less understood. Dopamine generally counteracts another chemical actylcholine which triggers muscle contractions.
-John
poster:JohnX
thread:56156
URL: http://www.dr-bob.org/babble/20010310/msgs/56453.html