Posted by steve on March 13, 2001, at 1:26:19
In reply to Re: Who was asking about CRF antagonists, posted by JohnX on March 12, 2001, at 5:07:39
I think NRGN and NBIX are both either in Phase Is or getting there. DuPont and Novartis are also working on them, as is Pfizer.
With luck, we looking at 5 yrs, though that's only a 50% probability. I have been told that it is expected that they will be the first meds to really do anything for PTSD.
Hope this helps,
And keep your head up.
> > There have been one or two posts lately asking about cortisol blockers or CRF antagonists. The following press release might be of some interest to you.
> >
> > Vince
> >
> > http://psychiatry.medscape.com/reuters/prof/2001/03/03.09/20010308drgd008.html
> > --------------------------------------------------------------------------------
> > Phase I Data Positive on CRF Receptor Antagonist for Depression, Anxiety
> > --------------------------------------------------------------------------------
> >
> > NEW YORK (Reuters Health) Mar 08 - Neurocrine Biosciences, of San Diego, said on Thursday that data from a phase I trial of its corticotropin releasing factor (CRF) receptor antagonist product for depression and anxiety indicate that the drug is well tolerated.
> >
> > According to Neurocrine, the company believes that the drug blocks stress responses mediated by CRF, resulting in anti-anxiety and anti-depressant effects.
> >
> > Additionally, the 48-patient single-dose study indicated rapid absorption, as well as good dose-proportionality and plasma half-lives of the CRF receptor antagonist that support a once-daily dosing schedule.
> >
> > A 2-week, multi-dose, dose-escalating trial is planned to evaluate the safety and endocrine profiles of the compound, the company said. Phase II trials are expected to follow.
>
> Hey that's good news. When would one expect a CRF-antagonist to potentially hit the market?
>
> I hope these treatments also show promise especially for PTSD patients where dysfunction in the HPA axis is hoped to the best place to target for 1st line treatment.
>
> -john
poster:steve
thread:56265
URL: http://www.dr-bob.org/babble/20010310/msgs/56348.html