Posted by JohnX on March 9, 2001, at 17:53:08
In reply to Re: How does Wellbutrin work ?, posted by terra miller on March 9, 2001, at 10:47:52
> so, according to all that i just read in this thread, i see nothing to do with serotonin. am i correct?
>
> i remember reading elsewhere here that wellbutrin very weakly effects serotonin. correct?
>
> is this why wellbutrin often is taken along with SSRI's/similar acting meds?
>
> everything is starting to add up, if i've got it right, that is. (do i?)
>
> terra.Terra,
You got it.
The action on serotonin is extrememly weak (negligible).
Most anti-depressants have some measurable amount
of action on many different types of receptors like serotonin,norepinephrine,dopamine,acetylcholine,gaba,glumtamate,etc.
But they usually are *very* targeted at a particular type or group of receptors, so the action on the other receptors is negligible.
The older tricylclic anti-depressants were less selective and had stronger action on cholinergic and muscanaric receptors etc, which lead to side effects and no additional tharapeutic action.-john
poster:JohnX
thread:54696
URL: http://www.dr-bob.org/babble/20010302/msgs/56050.html