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Re: appended

Posted by danf on March 2, 2001, at 6:57:26

In reply to Re: How do SR tablets differ from non SR tablets?, posted by danf on March 2, 2001, at 6:46:23

It is a physical process. some ( lots of med capsules )are made into tiny beads. beads are coated with different layers of a slow dissolving medically inert material.

there are several 'tricks' used. some are pH dependent, granule size, inert binder amounts, etc

most common method uses varying granule size & different coating thickness. so that some granules dissolve immediately, some in 1 hr, some in 2, etc.

dissolve time has to be played against gut transit time. over more than about 8-10 hrs & meds will be in the colon & have erratic absorption.


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