Posted by PhoenixGirl on February 13, 2001, at 18:09:02
In reply to Mirapex will be the next Remeron of ADs, posted by SalArmy4me on February 13, 2001, at 4:05:11
I'm treatment resistant too. I want to try mirapex, but have heard that it causes terrible nausea. How slowly should it be increased, and does the nausea go away? When I first tried selegiline (deprenyl), another dopamine agonist, my stomach hurt a lot. But lately I've tried it again, and have had no stomach problems. When I tried it the first time, I was on celexa and a high dose of wellbutrin, but now I'm on desipramine and moderate dose of wellbutrin. Thanx.
> First, the background: I have treatment-resistant depression with painful flashbacks and Obsessive-Compulsive Disorder.
>
> Mirapex started working for me in a little less than a week (possibly because I got up to 6 mg per day in two days' time)! I found out that it needs to be taken about every 5 hours, otherwise I relapse. I have no side-effects from it (thank God).
>
> Mirapex is a dopamine agonist that is most often used for Parkinson's Disease. But, it has been shown in two studies to have antidepressant properties in non-Parkinson's patients.
>
> Studies on Medline:
> 2. Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review Ann Clin Psychiatry. 2000 Sep;12(3):137-40. [Record as supplied by publisher] PMID: 10984002
> 3:
> Maj J, Rogoz Z.
> Related Articles
> Synergistic effect of pramipexole and sertraline in the forced swimming test. Pol J Pharmacol. 1999 Nov-Dec;51(6):471-5.
> PMID: 10817524
> 4: Corrigan MH, Denahan AQ, Wright CE, Ragual RJ, Evans DL. Related Articles Comparison of pramipexole, fluoxetine, and placebo in patients with major depression. Depress Anxiety. 2000;11(2):58-65. PMID: 10812530
> 5: DeBattista C, Solvason HB, Breen JA, Schatzberg AF. Related Articles Pramipexole augmentation of a selective serotonin reuptake inhibitor in the treatment of depression. J Clin Psychopharmacol. 2000 Apr;20(2):274-5. No abstract available. PMID: 10770475
> 6:
> Goldberg JF, Frye MA, Dunn RT.
> Related Articles
> Pramipexole in refractory bipolar depression.
> Am J Psychiatry. 1999 May;156(5):798. No abstract available.
> PMID: 10327923
> 7:
> Bennett JP, Piercey MF.
> Related Articles
> Pramipexole--a new dopamine agonist for the treatment of Parkinson's disease. J Neurol Sci. 1999 Feb 1;163(1):25-31. Review.
> PMID: 10223406
> 8: Piercey MF. Related Articles Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease. Clin Neuropharmacol. 1998 May-Jun;21(3):141-51. Review. PMID: 9617505
> 9:
> Willner P.
> Related Articles
> The mesolimbic dopamine system as a target for rapid antidepressant action. Int Clin Psychopharmacol. 1997 Jul;12 Suppl 3:S7-14. Review.
> PMID: 9347387
poster:PhoenixGirl
thread:53858
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