Posted by SLS on February 5, 2001, at 18:12:44
In reply to Wondering if there's tolerance with mazindol... , posted by PhoenixGirl on February 5, 2001, at 15:44:43
> This is a weight loss drug that can help with depression. My book on prescription pills says that it is not technically an amphetamine, but later says that it shouldn't be taken for more than a few months. I don't really care if it's addictive, since I already know that I will need medical treatment of depression for the rest of my life, but does it produce tolerance? At this point, I'm considering rotating stimulant-type drugs if that will avoid the problem with tolerance. Like 3 months ritalin, 3 months adderall, 3 months of this mazindol stuff. I just never hear about mazindol, and I'm wondering why.
I have been interested in Mazindol for quite some time. It was originally researched as an antidepressant. It inhibits the reuptake of both NE and DA. I had thought to use this drug as a substitute for the dopaminergic drug amineptine, which is no longer available. It might make an ideal drug to combine with low-dose amisulpride or any antidepressant drug combination for which a stimulant is indicated. Mazindol is considered to be a psychostimulant, but I don't think it is as liable to cause addiction as is Ritalin or Adderal. I am not sure it makes sense to cycle between different psychostimulants in an effort not to become addicted. True addiction and abuse involves a behavioral and compulsive need to satisfy a craving. To simply become dependant on a drug - let's say insulin - is not addiction. It is called treatment.As far as tolerance to mazindol is concerned, it does occur for its antiobesity properties. I kind of doubt that the same can be said for any antidepressant properties this drug may have.
Are there any therapeutic advantages to rotating between drugs?
Thanks.
- Scott
poster:SLS
thread:53365
URL: http://www.dr-bob.org/babble/20010131/msgs/53378.html