Posted by Sunnely on January 26, 2001, at 0:26:09
In reply to Re: Celebrex aggravating depression! WHY?, posted by Ted R on January 25, 2001, at 21:53:57
> > I really believe that you have overstated the potential or depressive response that can occur probably idiosyncratically with NSAIds. If you are talking about DMARDS, really aggressive anti-inflammatories used for severe immune response diseases such as Rheumatoid Arthritis, then you might be on to something. As these types of Drugs, such as methotrexate or some of the really potent corticosteroids, most effectively and primarily impact cytokines, TNF bodies, and macrophages, and not your simpler and purer prostaglandin inhibitors such as Celebrex or Naprosyn. The FDA for what it is worth, has always stated "causal relationship not established" for NSAids and the occurence of depression. I am curious as to what references or studies, that you are citing....TEdR
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Hi TedR,
Here's the source of my response:
Sussman N, Magid S: Psychiatric manifestations of nonsteroidal anti-inflammatory drugs. Primary Psychiatry 2000;7(9):26-30.
poster:Sunnely
thread:51763
URL: http://www.dr-bob.org/babble/20010122/msgs/52596.html