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Re: Neurontin 800mg » allisonm

Posted by Cam W. on January 17, 2001, at 21:54:29

In reply to Re: Having a difficult time with Neurontin » Cam W., posted by allisonm on January 17, 2001, at 20:01:20

Allison - Is the 800mg formulation sustained release. This would mean that the Neurontin would absorb slower over a longer period of time, thus not allowing saturation of the active transport system (ie all of the 800mg is not absorbed at once, only a little at a time, allowing the transporter to "ferry" the Neurontin into the blood stream and then come back for more Neurontin in the intestine). Therefore saturation does not take place. I am not sure of this, but it would seem the most plausible explanation.

Either that, or the company does not know the pharmacokinetics of their own drug (which I doubt). A sustained released formulation would theoretically improve medication compliance because you would not have to take the medication as often (eg twice a day dosing, rather than three of four times daily).

Hope this helps - Cam


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poster:Cam W. thread:51773
URL: http://www.dr-bob.org/babble/20010111/msgs/51914.html