Posted by dennis on January 2, 2001, at 21:09:50
In reply to Re: cannabis, posted by JohnL on January 1, 2001, at 17:20:48
Experiments with stoned rats suggest the drug reduces the amount of corticotrophin-releasing factor (CRF) in the amygdala. Excess secretion of CRF is associated with abnormalities in the HPLA axis and depression. The rebound surge of CRF on ceasing cannabis-use is associated with increased vulnerability to stress and a withdrawal-reaction, arguably one good reason not to stop in the first instance. A dysfunctional response to stress, linked to a chronically overractive HPLA axis, causes anxiety disorders and depression.
This is something I found on the web, it might help explain how cannabis can have antidepressant effects and why it can relieve stress, do you know of any other drug that reduces the amount of corticotrophin-releasing factor in the amygdala?
poster:dennis
thread:50629
URL: http://www.dr-bob.org/babble/20001231/msgs/50783.html