Posted by SLS on December 13, 2000, at 21:22:00
In reply to Re: hyperthyrodism and cyclothymia, posted by SLS on December 13, 2000, at 20:23:27
Here are a couple of relevant abstracts I came across:
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10: Psychiatry Res 1997 Aug 29;72(1):1-7Rapid cycling bipolar affective disorder: lack of relation to hypothyroidism.
Post RM, Kramlinger KG, Joffe RT, Roy-Byrne PP, Rosoff A, Frye MA, Huggins T
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA.
Thyroid indices were measured after an extended period of medication-free evaluation averaging 6 weeks in 67 consecutively admitted patients with bipolar illness. Thyroid hormone levels -- thyroxine (T4), free T4 and triiodothyronine (T3) -- were not significantly different in the 31 rapid cyclers ( > or = 4 affective episodes/year) than in 36 non-rapid cyclers. Analysis of covariance indicated a non-significant trend relation between higher T4 and a greater number of affective episodes in the year prior to admission and male gender when age was covaried. Several previous reports, primarily in medicated subjects, have suggested a link between rapid cycling patients and decreased peripheral thyroid indices (low hormone levels and elevated TSH), but now the majority of studies do not support such a relation. Among those in the literature, this study includes patients studied for the longest time off medications and further suggests that the commonly-cited relation between subclinical hypothyroidism and rapid cycling bipolar illness be reevaluated.
Publication Types:
Review
Review, tutorialPMID: 9355813, UI: 98015890
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2: Eur Psychiatry 1999 Oct;14(6):341-5Evaluation of thyroid function in lithium-naive bipolar patients.
Valle J, Ayuso-Gutierrez JL, Abril A, Ayuso-Mateos JL
Department of Psychiatry, Hospital de la Princesa, Madrid, Spain.
A high prevalence of thyroid hypofunction has been found in bipolar patients. However, the samples used in previous studies included a high percentage of patients in treatment with lithium and carbamazepine. Since the use of these drugs may explain the high prevalence of thyroid disturbances found in bipolar patients, we designed the present study to assess thyroid function in a sample of bipolar patients who had not been treated previously with lithium or carbamazepine. Patients included in the sample met Research Diagnostic Criteria for bipolar affective disorder. Assessment included determination of serum levels for total tyroxine (T4), total triiodothyronine (T3), and thyrotropin both basally and in response to infusion of 500 mg of Protilerin. The rate of thyroid hypofunction in the total sample (9.2%) was considerably lower than that reported in other studies with bipolar patients undergoing lithium therapy. Five patients (9.2%) showed some thyroid hyperfunction parameter. Our results do not show significant differences in thyroid function indices between long-term and short-term duration of illness, between outpatients and inpatients, between high and low number of episodes, and between rapid- and non-rapid-cycling cases. Comparison between bipolar I and bipolar II patients shows a statistically significant difference in the values of TSH levels, with the bipolar II group having a higher mean value. Our data suggest that thyroid dysfunction is not related to gender, duration of illness, number of episodes, or rapid-cycling course of illness. The higher TRH-stimulated TSH levels in the bipolar II group could be considered a differential biological feature.
PMID: 10572366, UI: 20048774
poster:SLS
thread:50469
URL: http://www.dr-bob.org/babble/20001130/msgs/50540.html