Posted by anita on November 24, 2000, at 22:29:17
In reply to Risperdal Zyprexa questions.Andrew,Cam,SLS,anyone, posted by JohnL on November 23, 2000, at 6:57:14
Hi John,
You forgot to ask me! ;-) I have looked everywhere for this type of information and have come up with nothing. Personally, I do think that very low doses of these atypical antipsychotics do in fact have a paradoxical effect, i.e. raise D2 levels in the mesolimbic pathway, in some way, tho I don't know if they would also antagonise the 5HT2 receptor. See my posts under Q. for Risperidal users.
For me at least, my response to Risperdal .25mg/day is quite similar to the response I had with low-dose amisulpride. If amisulpride worked for you, I would give very low dose Risperdal or Zyprexa a try -- really.
anita
I have been searching everywhere for information on Risperdal and Zyprexa. It is well documented that Amisulpride blocks presynaptic D2 at low doses, and post synaptic at higher doses. I am trying to find similar information for Risperdal and Zyprexa.
>
> All I can find talks about D2 occupancy or D2 binding, but no mention of presynaptic or postsynaptic. That to me seems like a hugely relevent topic, and I am amazed I can't find any mention of it anywhere. Does anyone know?
>
> It seems apparent from discussions at this board that varying doses of these drugs have different effects. That implies there could be differences in presynaptic or postsynaptic binding depending on dose size. But I can't find any info on that topic. ???
>
> It amazes me that so much more is known about a European drug (Amisulpride) which has relatively little funding compared to the heavyweight makers of Risperdal and Zyprexa researchers. Weird.
>
> Anyway, can anyone share information on presynaptic and postsynaptic actions of Risperdal or Zyprexa at various doses? I sure can't find it anywhere.
> Thanks,
> John
poster:anita
thread:49296
URL: http://www.dr-bob.org/babble/20001115/msgs/49376.html