Posted by dj on November 14, 2000, at 16:18:14
In reply to Interesting site: Skeptical Psychiatrist..SLS, etc, posted by dj on November 14, 2000, at 16:11:21
http://home.gci.net/~dougs/antidepr.htm
"Role of Norepinephrine in Depression, by Delgado P, and Moreno F. J ClinPsychiatry 2000; 61[suppl 1]: 5-12
If patients on SSRI's are deprived of serotonin, they tend to become depressed again, whereas those on desipramine become depressed when deprived of norepinephrine. This suggests that SSRI's have their mechanism of action through the serotonin system, and desipramine through norepinephrine. However, "the neurobiologic basis of depression remains unknown." The same studies that gave the above results also found, contrary to the authors' hypothesis, that unmedicated depressed patients as well as healthy volunteers were unaffected by being deprived of either serotonin or norepinephrine. This suggests that antidepressants "work" not by correcting chemical abnormalities, but by creating them (the sensitivity to such deprivation is abnormal). Antidepressants mask depression. When the mask is lifted, the depression is still there.> > > > > > >
Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: Effects of depression and antidepressant treatment, by Sargent P, Kjaer K, Bench C, Rabiner E, Messa C, Meyer J, Gunn R, Grasby P & Cohen P. Arch Gen Psychiatry. 2000;57:174-180
Many believe depression to be caused by decreased serotonin neurotransmission, however, "the precise nature of this putative deficit has remained elusive." This study briefly reviewed existing data and formed the hypothesis that "5-HT1A receptor binding would be decreased in depressed subjects... both at presynaptic... and postsynaptic sites..., and that long-term SSRI treatment would further reduce 5-HT1A receptor binding in the raphe nuclei." This seems to be saying that antidepressants worsen the abnormality in the raphe nuclei, but in so doing, make things better elsewhere..."
poster:dj
thread:48803
URL: http://www.dr-bob.org/babble/20001102/msgs/48805.html