Posted by Maniz on November 3, 2000, at 16:21:20
In reply to Re: naphazoline AndrewBRe: Andrew: social anxiety meds, posted by AndrewB on November 1, 2000, at 1:17:42
Hi,
I tried the naphazoline under the tongue (two drops).
I think it works. It is subtle so it is a bit subjective, but after trying it the second time I found I was doing things, especially like putting order in my home.
Side effect, possibly a bit nervous like feeling blood pumps, sory I can not tell more precicely.
I do not know what could be the problem with sublingual administration. Rebound congestion?.
Regarding eye or nasal drops, the Merk site mentions the possibility of the same side effects for both.
I searched for oral administration of naphazoline and could not find much.
Another drug mentioned as a an alpha 1 agonist is phenylephrine which is administered orally for the same casses as naphazoline.
> Naphazoline can create a good arousal effect in some people.
>
> Rebound nasal congestion is a concern with nasal drops.
>
> Eye drops are therefore less problematic.
>
> Price may not be a problem. S.D. posted on 6-15 with the heading 'BauschLomb All Clear AR has Naph. .03% for $4'.
>
> Sublingual administration may or may not be effective. Can liquid preperations be absorbed effectively sublingually? Let me know if you try this mode though. Oral ingestion I wouldn't bother with.
>
> Note that Naphazoline can be effective because it is an Alpha 1 agonist. Therefore it works on a very specific part of the andrenergic (NE) system. General upregulation of NE activity may not have the same beneficial effects.
>
> Specifically, ephedra should not be used as an arousal agent because, due to its mode of action, it rapidly causes tolerance and depletion of NE.
>
> Many people will expereince tolerance to the effects fo Naphazoline overtime. Some don't though and Dr. Goldstein has indicated that in such cases it can be used on an ongoing basis as an arousal agent.
>
> Tyrosine is ususually ineffective. Though it is converted to dopamine and NE, the body usually has sufficient quantities of this amino acid. A rate limiting step of converting the tyrosine to the neurotransmitters usually prevents supplemental tyrosine from raising NE and dopamine levels.
>
> L-phenylalanine can be an arousal agent in some. Some will expereince anxiety, agitation or other neg. side effects with it. Some evidence indicates that phenylalanine is not effective for long-term use.
>
> A positive response to Naphazoline may indicate a positive response to the NE reuptake inhibitor reboxetine.
>
> Some people experience less anxiety on some NE meds, most notably clonidine. Naphazoline and Rebox are unlikely to reduce anxiety.
>
> AndrewB
poster:Maniz
thread:36908
URL: http://www.dr-bob.org/babble/20001102/msgs/48140.html