Posted by Sassy on November 1, 2000, at 19:26:11
In reply to Correction to above post » Cam W., posted by Cam W. on November 1, 2000, at 19:07:29
CAM,
You've probably been repeating the same information to someone else someplace else
in the site. Thank you for the information.I do try to spend as much time researching, but but with the time I do, don't feel I'm getting anywhere. I tell you, sometimes trying to get use to these drugs, when you have to really think, you realize how much your mind is messed up. That's a feeling I hate, and to be honest, time I can't afford.
This search gets frustrating sometimes, but I always seem to come back and try again. I do see others are going through the same thing. Hope we strike oil soon.
Thanks again,
Sassy> •Oops, looked down at the journal article beside me. It is the serotonin-2C (5-HT2C) receptor that is implicated in weight gain, not the 5-HT3 receptor (stimulation of that receptor causes tummy upset).•
>
> •AMENDED VERSION•
>
> Sassy - H2-receptor antagonists (aka H2- recptor blockers) may work to decrease weight gain by some unknown mechanism, but I haven't personally seen it work. There are anecdotal reports (aka letters to the editor) of cimetidine (Tagamet™) and nizatidine (Axid™) working to stop the weight gain from occuring, but is not used in weight loss (I think).
>
> As for the theories of serotonergic antidepressants (SSRIs, Remeron™, Serzone™) causing weight gain. There are probably several events occuring. The increased serotonin is probably stimulating serotonin-2C receptors (5-HT2C), which has been shown to increase weight. I believe that Remeron blocks histamine (H-1) receptors which also causes weight gain. People often mention a craving for carbohydrates. There are other theories, but I can't think of them right now. I know that Clozaril™ (clozapine) and Zyprexa™ (olanzapine) can cause increased levels of leptin in the plasma, which is also implicated in weight gain. I'm not sure if leptin levels are raised with serotonergic antidepressant use.
>
> Keeping a food diary (of what you are eating) and trying to eat healthier (I'm one to talk) and moderate daily exercise can help shift some of that weight around (lose fat & gain muscle).
>
> Hope this helps - Cam
poster:Sassy
thread:46967
URL: http://www.dr-bob.org/babble/20001022/msgs/47960.html