Posted by danf on October 26, 2000, at 14:07:43
In reply to Re: pindolol ?, posted by JahL on October 26, 2000, at 13:22:54
I would be surprised if pindolol worked with serzone.
The little known about pindolol & mechanisms, suggests that it blocks adaptation of the synapse to higher levels of serotonin. This adaptation has been postulated as the reason for partial response & then later failure of SSRIs. If the primary AD does not work by increasing synaptic serotonin levels, one would guess that pindolol would not have a high likelyhood of working.
Since serzone is a potent serotonin agonist ( which means it simulates higher levels of serotonin ), serzone may block the receptor that pindolol works on, or it may not. Since pindolol only works about 50% of the time, it is not a perfect answer. Also one would expect it to fail 1/2 of the time.
Controlled studies have shown pindolol to be effective about 50% of the time in retrieving an SSRI failure after an initial partial response of the SSRI.
There has not been a report that pindolol works in combination with non-SSRI anti-depressants in a regular consistant way.
It is most effective in blocking physical effects of anxiety. The 5mg TID dosage mentioned above also may be too low. An indicator of this may be if there remained physical signs of anxiety, such as increased heart rate, etc
poster:danf
thread:47282
URL: http://www.dr-bob.org/babble/20001022/msgs/47423.html