Posted by Cam W. on October 20, 2000, at 19:35:48
In reply to Re: CAM W. / Ant-Rock Questions, posted by Judy on October 19, 2000, at 20:33:21
> I haven't visited this board for a long time but the last time I participated, Anthony mentioned a doctor from down South, I believe, who regularly prescribed the combination of Parnate and Selegiline with good results.
>
> Anthony: Did you ever consider that combination? Do you remember the doctor's name and might he be written up on the internet somewhere?
>
> Cam: What is your learned opinion of that combination? What's the worst case scenario.
>
> I ask because I unsuccessfully took Selegiline for about six months, weaned off and started Parnate this past spring. The first week I took Parnate, I felt wonderful, then the bubble burst and I've been in a limbo of not-quite-depressed but definitely anhedonic ever since. I've been told that the initial mania had nothing whatsoever to do with selegeline remaining in my system, but I still can't help wondering...Judy - As a caveat I'd like to say that I have limited experience with MAOIs, as they are seldom used in the population of people that I fill prescriptions for (actually, I don't think that I even carry Parnate in the store). Others on this board have much more experience with MAOIs than I do.
At therapeutic doses (no more than 10mg/day) selegiline (Eldepryl™) is a selective, irreversible inhibitor of MAO-B. Parnate™ (tranylcypromine) is an irrevesible inhibitor of both MAO-A and MAO-B. Other than perhaps being able to use lower doses of each when given together, I can't think of any reason to do so (but again, I lack real-life experience with MAOIs). Maybe the southern doc has fewer problems with the "tyramine effect" with this combination; I don't know.
Hopefully someone else can shed light on your question - Cam
poster:Cam W.
thread:46685
URL: http://www.dr-bob.org/babble/20001012/msgs/46915.html