Posted by anita on October 8, 2000, at 19:04:12
In reply to Re: Help -- Looking for ritanserin (PeterJ?), posted by SLS on October 8, 2000, at 13:28:41
Hiya Scott,
I'm interested in 5HT2A antagonism because it may help with the negative symptoms of schizophrenia, which are similiar to certain aspects of my depression, particularly apathy and lack of motivation. Theoretically, SSRIs (I'm on Zoloft) that increase 5HT2A can cause a resultant decrease in dopamine particularly in the mesocortical areas, thereby (via the medial prefrontal cortex) resulting in negative-like symptoms.
Zyprexa and remeron are out because of the weight gain problem. Uncertain if I can add serzone to zoloft (do you know?). Looking into the potency of 5HT2A antagonism in cyproheptadine. Will try risperidone if I can't get ziprasidone, ritanserin, or ketanserin. Do you know if ketanserin is available?
Any comments?
:-),
anita
> > what is ritanserin?
>
> Ritanserin is a compound that is perhaps the most potent antagonist (blocker) of serotonin 5-HT2 receptors. 5-HT2 receptor blockade is a property shared by trazodone (Desyrel), nefazodone (Serzone), and mirtazapine (Remeron).
>
> Anita, I tried to post a reply to your question the other day, but probably forgot to confirm its submission. To the best of my knowledge, ritanserin is not currently marketed anywhere in the world.
>
> I am extremely curious, Anita. What you interest in ritanserin?
>
>
> - Scott
poster:anita
thread:45919
URL: http://www.dr-bob.org/babble/20000926/msgs/45976.html