Provigil NOT Dopamine Re-Upt Inhibitor

Posted by Darby on September 21, 2000, at 22:19:09

In reply to Re: Amantadine work for anybody?, posted by JohnL on September 18, 2000, at 4:35:27

I must disagree with the description of modafinil (Provigil) as a dopamine reuptake inhibitor. The only information I'm aware of that it has any dopaminergic action at all relates to very limited secondary actions on dopamine in the nucleus accumbens of the brain. Modafinil seems to be primarily a noradrenergic-acting compound with some GABA reducing actions. Its dopaminergic actions seem to be very limited.
Thanks,
Darby

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